Gamma-cyclodextrin (γ-CD) is a cyclic α-(1,4)-linked oligosaccharide consisting of eight glucose molecules. Like other cyclodextrins, γ-CD can form inclusion complexes with a variety of organic molecules because the inner side of the torus-like molecule is less polar than the outer side.
Nanodrugs have been widely investigated for combating the large number of side effects associated with conventional therapeutics. Several investigations of such nanomedicines have demonstrated the profound role of nanoparticle size in therapeutic efficacy. Herein, we report the role of cyclodextrin …
Gamma-cyclodextrin (gamma-CD) is a cyclic alpha-(1,4)-linked oligosaccharide consisting of eight glucose molecules. Like other cyclodextrins, gamma-CD can form inclusion complexes with a variety .
pathway. Absorption of intact γ-Cyclodextrin is minimal at an estimated 0.02%. Toxicity Data provided by the applicant demonstrates that γ-Cyclodextrin is of low acute toxicity, with no evidence of toxicity at doses as high as 16 g/kg bw/day in mice, and 8 g/kg bw/day in rats.
(2-Hydroxypropyl)-gamma-cyclodextrin Target organs No specific target organs known. SECTION 12: Ecological Information Ecotoxicity Not regarded as dangerous for the environment. However, large or frequent spills may have hazardous effects on the environment. 12.1. Toxicity Toxicity Based on available data the classification criteria are not met .
Keywords: Methyl-β-cyclodextrin, toxicity, caspase, Bcl-2, Bcl-X L, and Bax. Introduction. Delivering lipophilic substances to the central nervous system (CNS) and nerve cells cultures requires the use of carrier molecules to ensure the predictable intracellular delivery to target cells.
Summary. The acute oral and parenteral LD-50 of beta-cyclodextrin was established on rats, mice and dogs. The long term toxicity studies were performed on rats and dogs following the two weeks dose finding studies given the test substance by oral route.
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Enhanced chemotherapeutic toxicity of cyclodextrin templated size-tunable rhodamine 6G nanoGUMBOS. Article (PDF Available) . b-CD), a nd gamma (g-CD) temp lates on t he size, .
Potential Impact of Cyclodextrin-Containing Formulations in Toxicity Evaluation of Novel Compounds in Early Drug Discovery. J Pharmaceu Pharmacol. 2014;2(1): 5. J Pharmaceu Pharmacol . toxicity in vivo, it is not foolproof as not all the compounds with gastrointestinal toxicity …
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Toxicity: ORL-RAT LD50 18800 mg kg-1, IPR-RAT LD50 356 mg kg-1, SCU-RAT LD50 3700 mg kg-1, IVN-RAT LD50 1008 mg kg-1, SCU-MUS LD50 412 mg kg-1 Oxford University Chemical Safety Data (No longer updated) More details
.beta.-Cyclodextrin - Investigated as a reproductive effector. Only select Registry of Toxic Effects of Chemical Substances (RTECS) data is presented here. See actual entry in RTECS for complete information..beta.-Cyclodextrin RTECS Number: GU2293000 Chronic Toxicological Effects: IARC ACGIH OSHA 7585-39-9 .beta.-Cyclodextrin hydrate n.a. n.a. n.a. n.a.
2-Hydroxylpropyl-beta-cyclodextrin (HP-beta-CD) is an alternative to alpha-, beta- and gamma-cyclodextrin, with improved water solubility and may be more toxicologically benign. . The toxicity .
Substance: Gamma cyclodextrin: GRN Number: 46: Intended Use: Use in bread spreads, frozen dairy desserts, ready-to-eat dairy desserts, desserts prepared from dry mixes, fruit fillings, cheese and cream fillings, and chewing gum as a stabilizer, emulsifier, carrier and formulation aid at varying levels
What are Trappsol® Cyclodextrins? Trappsol® is the trade name given to the Cyclodextrins that CTD, Inc. provides to its customers. The Trappsol® name assures you the Cyclodextrin you purchase is of the finest possible quality.
Hydroxypropyl-β-Cyclodextrin is a water-soluble cellulose derivatives synthesized and were used in large quantities in a variety of industrial products. Conjugation of Cisplatin with Hydroxypropyl-β-Cyclodextrin results in a significant increase in drug solubility thereby increasing its cytotoxic activity evident by the decreased LC 50 values.
γ-Cyclodextrin ≥98% Synonym: Cyclomaltooctaose, Cyclooctaamylose, Schardinger γ-Dextrin, gamma-Cyclodextrin CAS Number 17465-86-0. Empirical Formula (Hill Notation) C 48 H 80 O 40. Molecular Weight 1297.12 . Beilstein/REAXYS Number 78740 . EC Number 241-482-4. MDL number MFCD00009595. PubChem Substance ID 24892736
Repeated dose toxicity - Rat - - Oral - No observed adverse effect level - 860 mg/kg(β-Cyclodextrine) RTECS: Not available To the best of our knowledge, the chemical, physical, and toxicological properties have not been thoroughly investigated.(β-Cyclodextrine) SECTION 12: Ecological information 12.1 Toxicity
Alpha-, beta-, and gamma-cyclodextrin are all generally recognized as safe by the U.S. FDA. They have been applied for delivery of a variety of drugs, including hydrocortisone, prostaglandin, nitroglycerin, itraconazol, chloramphenicol. The cyclodextrin confers solubility and stability to these drugs.
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Gamma-cyclodextrin (gamma-CD) is a cyclic alpha-(1,4)-linked oligosaccharide consisting of eight glucose molecules. Like other cyclodextrins, gamma-CD can form inclusion complexes with a variety of organic molecules because the inner side of the torus-like molecule is less polar than the outer side.
The most abundant cyclodextrins are alpha, beta and gamma cyclodextrin which have 6,7 and 8 glucose units respectively. The interior cavity is hydrophobic and the …
Sugammadex is an octasaccharide derivative that is gamma-cyclodextrin in which all eight primary hydroxy groups are replaced by 2-(carboxyethyl)sulfanyl groups. Used (as the octasodium salt) for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery. It has a role as a neuromuscular agent.
GAMMA-CYCLODEXTRIN GAMMA-CYCLODEXTRIN: TOXICITY AND IRRITATION" No significant acute toxicological data identified in literature search. Section 12 - ECOLOGICAL INFORMATION No data Section 13 - DISPOSAL CONSIDERATIONS Disposal Instructions All waste must be handled in accordance with local, state and federal regulations.
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Cyclodextrin structure Due to the lack of free rotation about the glycosidic bonds and chain conformation of glucose units, CDs dis - play a torus-like or hollow truncated cone shape. In this peculiar structure (Figure 3), the secondary hydroxyl FIGURE 3 - β-cyclodextrin (β-CD) structure, with representations
Jan 17, 2019· Natural Cyclodextrin Main Beta Cyclodextrin Derivatives Other Beta Cyclodextrin Derivatives Alpha Cyclodextrin Derivatives Gamma Cyclodextrin Derivatives Cyclodextrin Inclusion Compounds Contact Us Tel: +8618653357776 Add: No 3666 West Baoshan Road,High-tech District,Zibo,Shandong,China Email：adminzbqianhui Feedback